A Unified Model Explaining the Offsets of Overlapping and Near-Overlapping Prokaryotic Genes
نویسندگان
چکیده
منابع مشابه
A unified model explaining the offsets of overlapping and near-overlapping prokaryotic genes.
Overlapping genes are a common phenomenon. Among sequenced prokaryotes, more than 29% of all annotated genes overlap at least 1 of their 2 flanking genes. We present a unified model for the creation and repair of overlaps among adjacent genes where the 3' ends either overlap or nearly overlap. Our model, derived from a comprehensive analysis of complete prokaryotic genomes in GenBank, explains ...
متن کاملOrigin and Length Distribution of Unidirectional Prokaryotic Overlapping Genes
Prokaryotic unidirectional overlapping genes can be originated by disrupting and replacing of the start or stop codon of one protein-coding gene with another start or stop codon within the adjacent gene. However, the probability of disruption and replacement of a start or stop codon may differ significantly depending on the number and redundancy of the start and stop codons sets. Here, we perfo...
متن کاملPurifying and directional selection in overlapping prokaryotic genes.
In overlapping genes, the same DNA sequence codes for two proteins using different reading frames. Analysis of overlapping genes can help in understanding the mode of evolution of a coding region from noncoding DNA. We identified 71 pairs of convergent genes, with overlapping 3' ends longer than 15 nucleotides, that are conserved in at least two prokaryotic genomes. Among the overlap regions, w...
متن کاملThe combinatorics of overlapping genes.
Overlapping genes exist in all domains of life and are much more abundant than expected upon their first discovery in the late 1970s. Assuming that the reference gene is read in frame +0, an overlapping gene can be encoded in two reading frames in the sense strand, denoted by +1 and +2, and in three reading frames in the opposite strand, denoted by -0, -1, and -2. This motivated numerous resear...
متن کاملOverlapping genes and information theory.
The discovery of overlapping genes in the viruses 4 x 1 7 4 and SV40 has generated a number of interesting questions. Here we are concerned with the contribution of information theory to the analysis of overlapping genes. The purpose of this letter is to comment on Yockey's 1979 application of information theory to these problems.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2007
ISSN: 1537-1719,0737-4038
DOI: 10.1093/molbev/msm145